Title:

  Drugwise: Growing Up Straight in a Chemical Culture
 Author:   Jim Parker
Publisher:   Do It Now Foundation

 Publication Date:

  September 2003

 Catalog No:

  212

Downers

No matter what else alcohol is--visible or invisible, silent or loud--it's only one member of a broader group of drugs called depressants or "downers."

Known medically as sedative-hypnotics--because of their ability to sedate (or reduce tension), and induce sleep (from the Greek word hypnos, for sleep)--they're probably better known simply as tranquilizers and sleeping pills.

Although there are dozens of different chemicals that produce depressant effects in dozens of different ways--all downers slow the flow of nerve impulses in the brain and central nervous system.

And they cause similar problems, too, given half a chance.

Tranquilizers. They were hailed as "wonder drugs" when they were introduced in the 1950s and '60s. And compared to other depressant drugs of the time, they did look pretty good for a while.

They were called "minor" tranquilizers--mostly to set them apart from the "major" tranquilizers used to treat serious forms of mental illness.

They were supposed to be both addiction-free and side-effect-free, and doctors around the world prescribed them throughout the '60s and '70s by the billions.

But as time went on (and problems linked to them became clear), the only thing "minor" about minor tranquilizers was their name.

It wasn't that they didn't work. They did. They were great at blocking normal feelings of anxiety or panic.

They worked so well, in fact that users hated to give them up--even after taking them for months or years. That's when it became clear they cause a problem they weren't supposed to cause--serious dependency and addiction.

Another thing everybody eventually figured out is that tranquilizers only tranquilize. They don't cure some mysterious disease that causes anxiety, or remove the source of worry. They simply
turn off parts of the brain that cause nervous feelings.

Nothing wrong with that--at least, not for people who are so stressed out that they need help even remembering what not being completely wired feels like. But that's also why minor tranquilizers today are prescribed only for short-term use--usually no more than eight weeks.

Some of the more common--and better known--tranquilizers are Valium®, Xanax®, and Ativan®. They come in a lot of shapes and colors and strengths, they just don't come in a form that makes tension or worry magically disappear. They may hide it for a while, but when it comes back, it's often stronger than before--like a mean genie who's been bottled up too long.

Sleeping pills. Sedative-hypnotics work in the same way. In fact, they turn down the brain so much that people can't even keep their eyes open, as they drift into serious slumberland.

For years, there were two basic kinds of sleeping pills: barbiturates and everything else. But that's changed. Although they were widely used in the past, barbiturates are a lot less common today.

There are two main reasons why. One is that they're so addictive. Another is that they easily cause overdose, especially when they're taken with alcohol.

Because of their risks, drug company researchers have stayed up nights for years trying to discover new drugs that knock people out as well as barbiturates, without the side effects and dangers.

But the problem with finding a side-effect-free sleeping pill has been a lot like the problem of finding a side-effect-free tranquilizer: There just doesn't seem to be one.

And many of the drugs developed as replacements have been every bit as risky, in their own ways.

Effects. The effects of downers are similar to the effects of alcohol. As dosage increases, inhibitions disappear, speech starts to slur, and body movements get clumsy and uncoordinated.

Downers are especially dangerous when used with alcohol. That's because both are removed from the body by the liver--and when both are circulating at the same time, alcohol gets priority and downers get bumped to "standby" status. When this happens, the downers recirculate, which prolongs their effect.

The combination effect of alcohol and downers is an example of a drug interaction known as synergism, which means that the effects of individual drugs are more intense in combination than either is alone. It's like the difference between multiplication and addition.

Three plus three may be six, but three times three is nine. And the more downers you multiply, the deadlier the result.


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This is one in a series of publications on drugs, behavior, and health published by Do It Now Foundation. Check us out online at www.doitnow.org.